Flights, accommodation, transfers: all booked in advance if possible.
Museums/attractions that require pre-booking: all done in advance.
Then we’ll have days planned out, usually by location with a couple of places to eat nearby already on the list, but we won’t set aside the exact order in which we do those days.
Then we check the weather forecast in the morning and decide which day we do (Eg Museum quarter if it’s wet, exploring if it’s dry, that kind of thing).